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Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.

Authors :
Shi B
Kitchen C
Weiser B
Mayers D
Foley B
Kemal K
Anastos K
Suchard M
Parker M
Brunner C
Burger H
Source :
Virology [Virology] 2010 Aug 15; Vol. 404 (1), pp. 5-20. Date of Electronic Publication: 2010 May 08.
Publication Year :
2010

Abstract

Characterization of residual plasma virus during antiretroviral therapy (ART) is a high priority to improve understanding of HIV-1 pathogenesis and therapy. To understand the evolution of HIV-1 pol and env genes in viremic patients under selective pressure of ART, we performed longitudinal analyses of plasma-derived pol and env sequences from single HIV-1 genomes. We tested the hypotheses that drug resistance in pol was unrelated to changes in coreceptor usage (tropism), and that recombination played a role in evolution of viral strains. Recombinants were identified by using Bayesian and other computational methods. High-level genotypic resistance was seen in approximately 70% of X4 and R5 strains during ART. There was no significant association between resistance and tropism. Each patient displayed at least one recombinant encompassing env and representing a change in predicted tropism. These data suggest that, in addition to mutation, recombination can play a significant role in shaping HIV-1 evolution.<br /> (Copyright 2010 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1096-0341
Volume :
404
Issue :
1
Database :
MEDLINE
Journal :
Virology
Publication Type :
Academic Journal
Accession number :
20451945
Full Text :
https://doi.org/10.1016/j.virol.2010.04.008