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Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
- Source :
-
Nature genetics [Nat Genet] 2010 Jun; Vol. 42 (6), pp. 492-4. Date of Electronic Publication: 2010 May 09. - Publication Year :
- 2010
-
Abstract
- Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 42
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 20453839
- Full Text :
- https://doi.org/10.1038/ng.585