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Guillain-Barré syndrome mimicking acute methotrexate-associated encephalopathy in an adolescent patient with lymphoblastic lymphoma.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2010 Nov; Vol. 32 (8), pp. 615-6. - Publication Year :
- 2010
-
Abstract
- We describe an adolescent case of Guillain-Barré syndrome (GBS) mimicking acute methotrexate-associated encephalopathy during chemotherapy for lymphoblastic lymphoma. Although initial presentations of hemiparesis and irritability were suggestive of acute encephalopathy, the diminished deep tendon reflexes and subsequent rapid progression to flaccid triparesis with bulbar palsy were consistent with GBS. After the initiation of intravenous immunoglobulin therapy her symptoms improved rapidly, and the diagnosis of GBS was confirmed by nerve conduction studies and cerebrospinal fluid examination in recovery phase. GBS should be considered in the differential diagnosis of acute methotrexate-associated encephalopathy, although GBS is a rare neurologic complication.
- Subjects :
- Adolescent
Antimetabolites, Antineoplastic adverse effects
Diagnosis, Differential
Female
Humans
Methotrexate adverse effects
Antimetabolites, Antineoplastic administration & dosage
Brain Diseases chemically induced
Brain Diseases diagnosis
Guillain-Barre Syndrome diagnosis
Methotrexate administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20463610
- Full Text :
- https://doi.org/10.1097/MPH.0b013e3181d204b1