Back to Search
Start Over
[The impact of diabetes mellitus and insulin interference on cortical SCF/KIT of mice].
- Source :
-
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2010 Feb; Vol. 26 (1), pp. 94-6. - Publication Year :
- 2010
-
Abstract
- Objective: To investigate the expression of cortical SCF/KIT system at different blood glucose level in mice.<br />Methods: 27 male C57 mice were randomly divided into control group, diabetes group, and diabetes plus insulin group. The diabetic mice were induced by streptozotocin. Western-blot and double-immunofluorescence histochemistry were used to detect the expression of SCF and KIT.<br />Results: Both methods indicate that the level of S-SCF and M-SCF were decreased significantly in the diabetes group, and this trend can be reversed effectively when the insulin was utilized.<br />Conclusion: The decline of SCF might be one of underlying mechanisms of diabetic encephalopathy.
Details
- Language :
- Chinese
- ISSN :
- 1000-6834
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
- Publication Type :
- Academic Journal
- Accession number :
- 20476577