[The impact of diabetes mellitus and insulin interference on cortical SCF/KIT of mice].

Objective: To investigate the expression of cortical SCF/KIT system at different blood glucose level in mice.
Methods: 27 male C57 mice were randomly divided into control group, diabetes group, and diabetes plus insulin group. The diabetic mice were induced by streptozotocin. Western-blot and double-immunofluorescence histochemistry were used to detect the expression of SCF and KIT.
Results: Both methods indicate that the level of S-SCF and M-SCF were decreased significantly in the diabetes group, and this trend can be reversed effectively when the insulin was utilized.
Conclusion: The decline of SCF might be one of underlying mechanisms of diabetic encephalopathy.