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Human NK cells display major phenotypic and functional changes over the life span.
- Source :
-
Aging cell [Aging Cell] 2010 Aug; Vol. 9 (4), pp. 527-35. Date of Electronic Publication: 2010 May 10. - Publication Year :
- 2010
-
Abstract
- Aging is generally associated with an increased predisposition to infectious diseases and cancers, related in part to the development of immune senescence, a process that affects all cell compartments of the immune system. Although many studies have investigated the effects of age on natural killer (NK) cells, their conclusions remain controversial because the diverse health status of study subjects resulted in discordant findings. To clarify this situation, we conducted the first extensive phenotypic and functional analysis of NK cells from healthy subjects, comparing NK cells derived from newborn (cord blood), middle-aged (18-60 years), old (60-80 years), and very old (80-100 years) subjects. We found that NK cells in cord blood displayed specific features associated with immaturity, including poor expression of KIR and LIR-1/ILT-2 and high expression of both NKG2A and IFN-gamma. NK cells from older subjects, on the other hand, preserved their major phenotypic and functional characteristics, but with their mature features accentuated. These include a profound decline of the CD56(bright) subset, a specific increase in LIR-1/ILT-2, and a perfect recovering of NK-cell function following IL2-activation in very old subjects. We conclude that the preservation of NK cell features until very advanced age may contribute to longevity and successful aging.
- Subjects :
- Adult
Aged
Aged, 80 and over
Cell Membrane metabolism
Cytotoxicity, Immunologic
Humans
Interferon-gamma biosynthesis
Lymphocyte Subsets cytology
Lymphocyte Subsets metabolism
Middle Aged
Phenotype
Receptors, Natural Killer Cell metabolism
Killer Cells, Natural cytology
Killer Cells, Natural metabolism
Longevity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1474-9726
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Aging cell
- Publication Type :
- Academic Journal
- Accession number :
- 20477761
- Full Text :
- https://doi.org/10.1111/j.1474-9726.2010.00584.x