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Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2010 Jun; Vol. 16 (6), pp. 715-23. Date of Electronic Publication: 2010 May 18. - Publication Year :
- 2010
-
Abstract
- Background: Memantine, an NMDA antagonist, is effective for moderate to severe Alzheimer's disease.<br />Objective: Determine whether memantine improves cognitive performance (CP) among subjects with multiple sclerosis (MS) and cognitive impairment (CI).<br />Methods: This double-blind, randomized, placebo-controlled trial (Clinicaltrials.gov NCT00300716) compared memantine 10 mg twice a day (4 week titration followed by 12 weeks on the highest tolerated dose) with placebo. The primary outcome was the change from baseline to exit on the Paced Auditory Serial Addition Test (PASAT) and the California Verbal Learning Test-II (CVLT-II) Long Delay Free Recall (LDFR). Secondary outcomes included additional neuropsychological tests; self-report measures of quality of life, fatigue, and depression; and family/caregiver reports of subjects' CI and neuropsychiatric symptoms.<br />Results: The differences between the groups on the change on the PASAT (placebo-memantine = 0.0 correct responses, 95% CI 3.4, 3.4; p = 0.9) and on CVLT-II LDFR (placebo-memantine =-0.6 words, 95% CI -2.1, 0.8; p = 0.4) as well as on the other cognitive tests were not significant. Subjects on memantine had no serious adverse events (AEs) but had more fatigue and neurological AEs as well as, per family members' reports, less cognitive improvement and greater neuropsychiatric symptoms than subjects on placebo.<br />Conclusion: Memantine 10 mg twice a day does not improve CP in subjects with MS, ages 18-65, without major depression, who have subjective cognitive complaints and perform worse than one SD below the mean on the PASAT or on the California Verbal Learning Test-II (total recall or delayed free recall).
- Subjects :
- Adolescent
Adult
Aged
Cognition Disorders complications
Cognition Disorders psychology
Depression psychology
Double-Blind Method
Fatigue psychology
Female
Humans
Male
Middle Aged
Multiple Sclerosis psychology
Neuropsychological Tests
Patient Selection
Quality of Life psychology
Surveys and Questionnaires
Treatment Outcome
Cognition Disorders drug therapy
Memantine therapeutic use
Multiple Sclerosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20483885
- Full Text :
- https://doi.org/10.1177/1352458510367662