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Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults.
- Source :
-
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2010 May; Vol. 104 (5), pp. 385-93. - Publication Year :
- 2010
-
Abstract
- Background: No data are available regarding the utility of fractional exhaled nitric oxide (FeNO) level in guiding therapy in smoking asthmatic patients. Identification of the effect of smoking in a large sample is needed.<br />Objective: To study the association between smoking and FeNO level according to current asthma and atopy status in adults from the French EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy).<br />Methods: Levels of FeNO were measured at 50 mL/s in 654 adults (268 asthmatic participants). Active smoking and environmental tobacco smoke (ETS) exposure at home, at work, and during leisure activities were recorded. Participants were categorized as having no exposure to ETS, mild exposure (ETS <2 h/d), and noticeable exposure (ETS > or = 2 h/d). Multivariate analyses were performed, with adjustment for age, sex, height, and center.<br />Results: Mean adjusted FeNO values increased with asthma (15.1 vs 19.5 ppb), atopy (14.2 vs 18.9 ppb), and eosinophilia (15.8 vs 24.8 ppb) (P < .001 for all). Mean FeNO levels decreased with smoking (18.4, 17.5, and 14.5 ppb in nonsmokers, ex-smokers, and current smokers, respectively; P for trend = .001). The association with smoking was observed in nonasthmatic and asthmatic participants, especially in atopic asthmatic participants. Multivariate analyses showed that ETS exposure of at least 2 h/d and active smoking were negatively and significantly associated with FeNO levels independent of age, sex, height, and center in nonasthmatic participants (mean [SE], -0.13 [0.06], P = .03 and -0.10 [0.03], P < .001) and in asthmatic participants (mean [SE], -0.18 [0.07], P = .01 and -0.14 [0.04], P = .02).<br />Conclusions: Active and passive smoking decreased FeNO levels in adults. Careful consideration of asthma, atopy, and active and passive smoking are needed to interpret FeNO values.
- Subjects :
- Adult
Asthma diagnosis
Asthma metabolism
Breath Tests methods
Dermatitis, Atopic diagnosis
Dermatitis, Atopic metabolism
Eosinophilia epidemiology
Eosinophilia metabolism
Exhalation
Female
France epidemiology
Humans
Male
Nitric Oxide analysis
Sensitivity and Specificity
Asthma epidemiology
Dermatitis, Atopic epidemiology
Nitric Oxide metabolism
Smoking metabolism
Tobacco Smoke Pollution
Subjects
Details
- Language :
- English
- ISSN :
- 1081-1206
- Volume :
- 104
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20486328
- Full Text :
- https://doi.org/10.1016/j.anai.2010.03.013