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Kidney and recipient weight incompatibility reduces long-term graft survival.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2010 Jun; Vol. 21 (6), pp. 1022-9. Date of Electronic Publication: 2010 May 20. - Publication Year :
- 2010
-
Abstract
- Long-term function of kidney allografts depends on multiple variables, one of which may be the compatibility in size between the graft and the recipient. Here, we assessed the long-term consequences of the ratio of the weight of the kidney to the weight of the recipient (KwRw ratio) in a multicenter cohort of 1189 patients who received a transplant between 1995 and 2006. The graft filtration rate increased by a mean of 5.74 ml/min between the third and sixth posttransplantation months among patients with a low KwRw ratio (<2.3 g/kg; P<0.0001). In this low KwRw ratio group, the graft filtration rate remained stable between 6 months and 7 years but then decreased at a mean rate of 3.17 ml/min per yr (P<0.0001). In addition, low KwRw ratios conferred greater risk for proteinuria, more antihypertensive drugs, and segmental or global glomerulosclerosis. Moreover, a KwRw ratio<2.3 g/kg associated with a 55% increased risk for transplant failure by 2 years of follow-up. In conclusion, incompatibility between graft and recipient weight is an independent predictor of long-term graft survival, suggesting that avoiding kidney and recipient weight incompatibility may improve late clinical outcome after kidney transplantation.
- Subjects :
- Adult
Body Weight physiology
Cohort Studies
Female
Follow-Up Studies
Humans
Hypertension epidemiology
Male
Middle Aged
Organ Size physiology
Proteinuria epidemiology
Retrospective Studies
Risk Factors
Transplantation, Homologous
Treatment Outcome
Graft Survival physiology
Kidney anatomy & histology
Kidney Transplantation physiology
Transplantation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1533-3450
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 20488949
- Full Text :
- https://doi.org/10.1681/ASN.2009121296