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Sexual dimorphic evolution of metabolic programming in non-genetic non-alimentary mild metabolic syndrome model in mice depends on feed-back mechanisms integrity for pro-opiomelanocortin-derived endogenous substances.
- Source :
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Peptides [Peptides] 2010 Aug; Vol. 31 (8), pp. 1598-605. Date of Electronic Publication: 2010 May 20. - Publication Year :
- 2010
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Abstract
- Previously, we showed that our post-natal handling model induces pro-opiomelanocortin-derived (POMC) endogenous systems alterations in male mice at weaning. These alterations last up to adult age, and are at the basis of adult hormonal and metabolic conditions similar to mild metabolic syndrome/type-2 diabetes. Here, we evaluate how sex influences post-natal programming in these metabolic conditions. Subjects are adult control (non-handled) female (NHF) and male (NHM) CD-1 mice; adult post-natal handled female (HF) and male (HM) mice. Handling consists of daily maternal separation (10 min) plus sham injection, from birth to weaning (21 days). In adult handled males (90-days old) we find not only POMC-derived hormones alterations (enhanced basal plasma corticosterone (+91%) and ACTH (+109%)) but also overweight (+5.4%), fasting hyperglycemia (+40%), hypertriglyceridemia (+21%), enhanced brain mRNA expression of hydroxysteroid(11-beta)dehydrogenase type-1 (HSD11B1) (+49%), and decreased mRNA-HSD11B2 (-39%). Conversely, uric acid, creatinine, HDL(C), total cholesterol, glucose and insulin incremental area under-the-curve are not affected. In females, post-natal handling does not produce both hormonal and dysmetabolic diabetes-like changes; but handling enhances n3- and n6-poly-unsaturated, and decreases saturated fatty acids content in erythrocyte membrane composition in HF versus NHF. In conclusion, for the first time we show that female sex in mice exerts effective protection against the hypothalamus-pituitary-adrenal homeostasis disruption induced by our post-natal handling model on POMC cleavage products; endocrine disruption is in turn responsible for altered metabolic programming in male mice. The role of sex hormones is still to be elucidated.<br /> (Copyright 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- 11-beta-Hydroxysteroid Dehydrogenase Type 1 genetics
11-beta-Hydroxysteroid Dehydrogenase Type 1 metabolism
11-beta-Hydroxysteroid Dehydrogenase Type 2 genetics
11-beta-Hydroxysteroid Dehydrogenase Type 2 metabolism
Adrenocorticotropic Hormone blood
Animals
Animals, Newborn
Brain metabolism
Corticosterone blood
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 etiology
Diabetes Mellitus, Type 2 metabolism
Female
Gene Expression Regulation, Enzymologic
Handling, Psychological
Hypothalamo-Hypophyseal System metabolism
Lipid Metabolism physiology
Male
Metabolic Syndrome blood
Metabolic Syndrome etiology
Metabolic Syndrome physiopathology
Mice
Pain Threshold physiology
Pituitary-Adrenal System metabolism
RNA, Messenger metabolism
Random Allocation
Stress, Psychological complications
Feedback, Physiological
Hypothalamo-Hypophyseal System physiopathology
Metabolic Syndrome metabolism
Pituitary-Adrenal System physiopathology
Pro-Opiomelanocortin metabolism
Sex Characteristics
Stress, Psychological physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5169
- Volume :
- 31
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Peptides
- Publication Type :
- Academic Journal
- Accession number :
- 20493223
- Full Text :
- https://doi.org/10.1016/j.peptides.2010.05.006