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Immunomodulatory effect of Eriobotrya japonica seed extract on allergic dermatitis rats.
- Source :
-
Journal of nutritional science and vitaminology [J Nutr Sci Vitaminol (Tokyo)] 2010; Vol. 56 (2), pp. 145-9. - Publication Year :
- 2010
-
Abstract
- We examined the immunomodulatory effect of Eriobotrya japonica seed extract (ESE) on rat allergic dermatitis elicited by repeated dinitrofluorobenzene (DNFB) application on the ear. Oral administration of ESE significantly inhibited development of allergic dermatitis based on lower ear thickness and serum immunoglobulin E (IgE) levels. Th1 cytokine interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), Th2 cytokine interleukin-4 (IL-4) and interleukin-10 (IL-10) in the lesional skin were determined. Oral administration of ESE significantly decreased IL-4 while significantly increasing IL-10 in lesional skin, and the lower levels of IFN-gamma and IL-2 were reversed by oral administration of ESE. The infiltration of eosinophils in the lesional skin was decreased by oral administration of ESE. These results suggested that ESE exerts anti-allergic actions by improving the balance of Th1/Th2 in allergic dermatitis.
- Subjects :
- Administration, Oral
Analysis of Variance
Animals
Cytokines blood
Cytokines drug effects
Dermatitis, Allergic Contact blood
Dermatitis, Allergic Contact complications
Disease Models, Animal
Ear
Edema etiology
Edema prevention & control
Enzyme-Linked Immunosorbent Assay methods
Immunoglobulin E blood
Immunosuppressive Agents blood
Male
Plant Extracts blood
Rats
Rats, Sprague-Dawley
Dermatitis, Allergic Contact prevention & control
Eriobotrya
Immunosuppressive Agents pharmacology
Plant Extracts pharmacology
Seeds
Subjects
Details
- Language :
- English
- ISSN :
- 1881-7742
- Volume :
- 56
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of nutritional science and vitaminology
- Publication Type :
- Academic Journal
- Accession number :
- 20495297
- Full Text :
- https://doi.org/10.3177/jnsv.56.145