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Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2010 Aug; Vol. 21 (8), pp. 2403-11. Date of Electronic Publication: 2010 May 25. - Publication Year :
- 2010
-
Abstract
- Cellulose acetate (CA) fibers loaded with the ester prodrugs of naproxen, including methyl ester, ethyl ester and isopropyl ester, were prepared through electrospinning using acetone/N,N-dimethylacetamide(DMAc)/ethanol (4:1:1, v/v/v) as solvent. The chemical and morphological characterizations of the medicated fibers were investigated by means of SEM, DSC, XRD and FTIR, as well as the studies of the drug release properties. The results indicated that the morphology and diameter of the fibers were influenced by the concentration of spinning solution, applied voltage, electrospun solvent and the surfactants. The average diameters of the fibers ranged between 100 and 500 nm for three prodrugs. There was good compatibility between CA and three prodrugs in the blended fibers, respectively. In vitro release indicated that constant drug release from the fiber was observed over 6 days. The prodrugs were successfully encapsulated into the fibers, and this system was stable in terms of effectiveness in release.
- Subjects :
- Administration, Cutaneous
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Cellulose chemistry
Cellulose metabolism
Drug Delivery Systems instrumentation
Esters chemistry
Esters pharmacokinetics
Lactic Acid chemical synthesis
Lactic Acid chemistry
Lactic Acid metabolism
Microscopy, Electron, Scanning
Microtechnology methods
Models, Biological
Naproxen administration & dosage
Naproxen chemistry
Naproxen pharmacokinetics
Polyglycolic Acid chemical synthesis
Polyglycolic Acid chemistry
Polyglycolic Acid metabolism
Polylactic Acid-Polyglycolic Acid Copolymer
Polymers chemical synthesis
Polymers chemistry
Polymers metabolism
Prodrugs chemistry
Prodrugs pharmacokinetics
Spectroscopy, Fourier Transform Infrared
Cellulose analogs & derivatives
Drug Delivery Systems methods
Esters administration & dosage
Prodrugs administration & dosage
Transdermal Patch
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 21
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 20499138
- Full Text :
- https://doi.org/10.1007/s10856-010-4100-y