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Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2010 Jul 01; Vol. 202 (1), pp. 117-24. - Publication Year :
- 2010
-
Abstract
- Background: Age and host genetics are important determinants of malaria severity. Lymphotoxin-alpha (LTalpha) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis.<br />Methods: We tested the association between rs7291467, a single-nucleotide polymorphism (SNP) in the LTalpha-related gene encoding galectin-2 (LGALS2), disease severity, and function in a case-control study of ethnic Highland Papuan adults and children with SM (n = 380) and asymptomatic malaria-exposed controls (n = 356) originating from a non-malaria-endemic region but residing in a lowland malaria-endemic area of Papua, Indonesia.<br />Results: The LGALS2 SNP showed a significant association with susceptibility to SM (including CM), in children (odds ratio, 2.02 [95% confidence interval, 1.14-3.57]) but not in adults. In SM, the C allele at rs7291467 was associated with enhanced galectin-2 transcript levels. In a separate group of Tanzanian children originating from a malaria-endemic region, we found preservation of the major ancestral LGALS2 allele and no association with susceptibility to CM.<br />Conclusions: Results suggest differences in the inflammatory contribution to the development of SM between children and adults in the same population and potential differences between individuals originating from malaria-endemic and non-malaria-endemic areas.
- Subjects :
- Adolescent
Adult
Age Distribution
Aged
Case-Control Studies
Child
Child, Preschool
Genetic Markers
Genetic Predisposition to Disease
Humans
Indonesia epidemiology
Infant
Introns
Malaria, Falciparum epidemiology
Middle Aged
Polymorphism, Single Nucleotide
Young Adult
Galectin 2 genetics
Malaria, Falciparum genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 202
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20500087
- Full Text :
- https://doi.org/10.1086/653125