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Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2010 May 28; Vol. 8, pp. 45. Date of Electronic Publication: 2010 May 28. - Publication Year :
- 2010
-
Abstract
- Background: Renal cell carcinoma (RCC) represents approximately 3% of all adult cancers and is more common in males. Systemic treatment for RCC has improved following the introduction of tyrosine kinase inhibitors, such as sunitinib. The molecular targets of sunitinib are receptor tyrosine kinases (RTKs). Moreover, sunitinib has an additional anti-angiogenic effect through its inhibition of the vascular endothelial growth factor receptor activation.<br />Case Presentation: We present a case of intra-abdominal abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment.<br />Conclusion: In the advancing era of molecular therapy of solid tumours, sunitinib has demonstrated significant efficacy in the post-cytokine setting treatment of metastatic renal cancer. Concurrently, however, increasing evidence has emerged to indicate that this class of drugs exert profound immunomodulatory effects on T cells and play major roles in immune tumor surveillance.
- Subjects :
- Abdominal Abscess surgery
Carcinoma, Renal Cell pathology
Disease Progression
Humans
Kidney Neoplasms pathology
Lung Neoplasms secondary
Male
Middle Aged
Positron-Emission Tomography
Prognosis
Sunitinib
Abdominal Abscess chemically induced
Angiogenesis Inhibitors adverse effects
Carcinoma, Renal Cell drug therapy
Indoles adverse effects
Kidney Neoplasms drug therapy
Lung Neoplasms drug therapy
Pyrroles adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20507643
- Full Text :
- https://doi.org/10.1186/1477-7819-8-45