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Nocturnal hypoxemia and periodic limb movement predict mortality in patients on maintenance hemodialysis.
- Source :
-
Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2010 Sep; Vol. 5 (9), pp. 1607-13. Date of Electronic Publication: 2010 May 27. - Publication Year :
- 2010
-
Abstract
- Background and Objectives: Sleep disorders, including sleep-disordered breathing and periodic limb movements during sleep, are associated with an increased risk for cardiovascular diseases, which are the leading causes of death in patients with ESRD. This study investigated the association between sleep disorders and mortality in patients with ESRD.<br />Design, Setting, Participants, & Measurements: Thirty patients on maintenance hemodialysis, who were clinically stable for >2 months, underwent overnight polysomnography to evaluate sleep parameters.<br />Results: All patients were followed for a median of 48 months (range: 14 to 62 months), and 14 of them died during the follow-up period. Among the sleep parameters, the percent of sleep time with arterial oxygen saturation <90% (T <90%), mean arterial oxygen saturation, and periodic limb movement index score were associated with significant increases in the risk of death. However, associations of the apnea-hypopnea index or oxygen desaturation index with mortality were NS. The hazard ratios (95% confidence intervals) for death per one SD increment in the log-transformed T <90% and periodic limb movement index score were 2.10 (1.06 to 4.15) and 2.48 (1.11 to 5.52), respectively, after adjusting for age.<br />Conclusions: We found that nocturnal hypoxemia and periodic limb movement during sleep, rather than apnea itself, were associated with an increased risk for death in patients with ESRD. However, conclusions from this study should be drawn with caution, because they are limited by the small sample size.
- Subjects :
- Adolescent
Adult
Aged
Biomarkers blood
Blood Proteins metabolism
Cause of Death
Female
Humans
Hypoxia blood
Hypoxia physiopathology
Kaplan-Meier Estimate
Kidney Failure, Chronic blood
Kidney Failure, Chronic physiopathology
Male
Middle Aged
Natriuretic Peptide, Brain blood
Nocturnal Myoclonus Syndrome blood
Nocturnal Myoclonus Syndrome physiopathology
Oxygen blood
Polysomnography
Proportional Hazards Models
Republic of Korea epidemiology
Risk Assessment
Risk Factors
Sleep
Sleep Apnea Syndromes blood
Sleep Apnea Syndromes physiopathology
Time Factors
Troponin T blood
Young Adult
alpha-2-HS-Glycoprotein
Hypoxia mortality
Kidney Failure, Chronic mortality
Kidney Failure, Chronic therapy
Nocturnal Myoclonus Syndrome mortality
Renal Dialysis mortality
Sleep Apnea Syndromes mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1555-905X
- Volume :
- 5
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical journal of the American Society of Nephrology : CJASN
- Publication Type :
- Academic Journal
- Accession number :
- 20507958
- Full Text :
- https://doi.org/10.2215/CJN.08881209