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Protective role of salidroside against aging in a mouse model induced by D-galactose.
- Source :
-
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2010 Apr; Vol. 23 (2), pp. 161-6. - Publication Year :
- 2010
-
Abstract
- Objective: To investigate the protective effects of putative AGEs (advanced glycation endproducts) inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose.<br />Methods: A group of 5-month-old C57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein (GFAP) and neurotrophin-3 (NT-3) in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined.<br />Results: D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 (IL-2) production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment.<br />Conclusion: Salidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model.
- Subjects :
- Aging, Premature blood
Aging, Premature chemically induced
Animals
Cerebral Cortex metabolism
Drugs, Chinese Herbal pharmacology
Galactose
Glial Fibrillary Acidic Protein
Glucosides pharmacology
Glycation End Products, Advanced blood
Interleukin-2 metabolism
Memory drug effects
Mice
Mice, Inbred C57BL
Motor Activity drug effects
Nerve Growth Factors metabolism
Nerve Tissue Proteins metabolism
Phenols pharmacology
Spleen drug effects
Spleen immunology
T-Lymphocytes drug effects
Aging, Premature prevention & control
Drugs, Chinese Herbal therapeutic use
Glucosides therapeutic use
Phenols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0895-3988
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biomedical and environmental sciences : BES
- Publication Type :
- Academic Journal
- Accession number :
- 20514993
- Full Text :
- https://doi.org/10.1016/s0895-3988(10)60047-5