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A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease.
- Source :
-
Mucosal immunology [Mucosal Immunol] 2010 Sep; Vol. 3 (5), pp. 487-95. Date of Electronic Publication: 2010 Jun 09. - Publication Year :
- 2010
-
Abstract
- The intestinal microbiome may have a critical roll in susceptibility or resistance to immune-mediated diseases. Alterations of the gut microflora after oral antibiotic treatment can regulate encephalomyelitis (EAE), an animal model for human multiple sclerosis (MS). We now show that a zwitterionic capsular polysaccharide A (PSA) of Bacteroides fragilis can protect against central nervous system demyelinating disease. Oral administration with purified PSA protected mice against EAE prophylactic and therapeutically. PSA treatment enhanced CD103 expressing dendritic cells (DCs) that accumulated in the cervical lymph nodes. Exposure of naïve DCs to PSA induced the conversion of naïve CD4(+) T cells into interleukin (IL)-10-producing FoxP3(+)Treg cells. Protection against EAE was completely abrogated in IL-10-deficient mice. Our results show an important role for a molecule from human commensal bacteria in protecting against EAE and suggest the possibility for protection in MS.
- Subjects :
- Administration, Oral
Animals
Antigens, CD biosynthesis
CD4-Positive T-Lymphocytes drug effects
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes metabolism
CD4-Positive T-Lymphocytes pathology
Cell Differentiation drug effects
Cells, Cultured
Dendritic Cells immunology
Dendritic Cells metabolism
Dendritic Cells pathology
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental microbiology
Encephalomyelitis, Autoimmune, Experimental prevention & control
Humans
Integrin alpha Chains biosynthesis
Interleukin-10 biosynthesis
Interleukin-10 genetics
Interleukin-10 metabolism
Lymphocyte Activation drug effects
Lymphocyte Activation genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Multiple Sclerosis drug therapy
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory metabolism
T-Lymphocytes, Regulatory pathology
Bacteroides fragilis immunology
Dendritic Cells drug effects
Encephalomyelitis, Autoimmune, Experimental immunology
Multiple Sclerosis immunology
Polysaccharides, Bacterial administration & dosage
T-Lymphocytes, Regulatory drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1935-3456
- Volume :
- 3
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Mucosal immunology
- Publication Type :
- Academic Journal
- Accession number :
- 20531465
- Full Text :
- https://doi.org/10.1038/mi.2010.29