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Effects of sulfurous, salty, bromic, iodic thermal water nasal irrigations in nonallergic chronic rhinosinusitis: a prospective, randomized, double-blind, clinical, and cytological study.
- Source :
-
American journal of otolaryngology [Am J Otolaryngol] 2011 May-Jun; Vol. 32 (3), pp. 235-9. Date of Electronic Publication: 2010 May 26. - Publication Year :
- 2011
-
Abstract
- Objectives: Nasal irrigations are mentioned among the adjunctive measures for treating several sinonasal conditions. Hyperchromatic supranuclear stria (HSS) in the ciliated cells (CCs) has recently been suggested as a potential cytological marker of the anatomofunctional integrity of nasal mucosa. The aim of this study was to compare the effects of nasal irrigations with sulfurous, salty, bromic, iodic (SSBI) thermal water or isotonic sodium chloride solution (ISCS) in patients with nonallergic chronic rhinosinusitis, considering the endoscopic, functional, microbiological, and cytological evidence (including the ratio of HSS-positive CCs to total CCs [the HSS+ rate]).<br />Methods: In a prospective, randomized, double-blind setting, 80 patients were recruited for nasal irrigations with SSBI water or ISCS for 1 month.<br />Results: An endoscopically assessed significant clinical improvement was seen after both SSBI thermal water and ISCS irrigations. Before treatment, Staphylococcus aureus was isolated in 5 patients in the SSBI thermal water group and 4 in the ISCS group. After the nasal irrigations, there was no sign of the bacteria in either group. Only the SSBI water irrigations significantly reduced total nasal resistance, as determined by rhinomanometry. Mild nasal irritation (6 cases) and episodes of extremely limited epistaxis (5 cases) were only reported after SSBI thermal water irrigations. Neither type of nasal irrigation significantly increased the mean HSS+ rate at cytological control after 1 month.<br />Conclusions: Both types of nasal irrigation improved the endoscopic and microbiological features of patients with nonallergic chronic rhinosinusitis, whereas only SSBI irrigations significantly reduced total nasal resistance. Further investigations are needed based on longer treatments and follow-up periods to establish whether the HSS+ rate is useful for monitoring clinical improvements in chronic rhinosinusitis treated with nasal irrigations.<br /> (Copyright © 2011. Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Aged
Bromides pharmacology
Chronic Disease
Double-Blind Method
Endoscopy methods
Female
Follow-Up Studies
Humans
Iodides pharmacology
Italy
Male
Middle Aged
Nasal Mucosa pathology
Prospective Studies
Rhinomanometry
Risk Assessment
Sodium Chloride pharmacology
Statistics, Nonparametric
Sulfur pharmacology
Therapeutic Irrigation methods
Treatment Outcome
Young Adult
Mineral Waters therapeutic use
Nasal Lavage methods
Rhinitis pathology
Rhinitis therapy
Sinusitis pathology
Sinusitis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-818X
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of otolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 20537762
- Full Text :
- https://doi.org/10.1016/j.amjoto.2010.02.004