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Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2010 Aug 30; Vol. 396 (1-2), pp. 39-44. Date of Electronic Publication: 2010 Jun 09. - Publication Year :
- 2010
-
Abstract
- The present study was aimed to investigate the effect of food components and dosing time on the oral exposure of nifedipine in rats. Nifedipine was given orally to rats with and without food components at 8:00a.m. (morning time) or 4:00p.m. (evening time) during winter periods. Food components included milk, sodium chloride, oleic acid, and sodium taurocholate. Plasma concentration profiles of nifedipine showed double peak phenomena which were generally retained regardless of food components, vehicle types and the dosing time. Sodium chloride, milk and sodium taurocholate significantly increased the AUC while oleic acid did not, when drug was dosed in the morning time. After the dosing in the evening time, milk and sodium chloride significantly increased the plasma concentrations of nifedipine but oleic acid and sodium taurocholate decreased them. Overall, the systemic in vivo exposure of nifedipine was invariably lower with the evening dosing compared to the dosing in the morning, but this circadian rhythm dependency was not reversed by the multiple dosing of food components in rats. Food components and dosing time significantly altered the oral pharmacokinetics of nifedipine in rats, implying that the altered bioavailability and higher plasma concentrations in the morning time may influence dosing regimens of nifedipine for hypertension patients.<br /> (Copyright 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Antihypertensive Agents blood
Drug Administration Schedule
Male
Milk
Nifedipine blood
Oleic Acid administration & dosage
Rats
Rats, Sprague-Dawley
Sodium Chloride, Dietary administration & dosage
Taurocholic Acid administration & dosage
Antihypertensive Agents administration & dosage
Antihypertensive Agents pharmacokinetics
Circadian Rhythm
Diet
Eating
Food-Drug Interactions
Nifedipine administration & dosage
Nifedipine pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 396
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 20538051
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2010.06.002