Back to Search
Start Over
Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jul 15; Vol. 20 (14), pp. 4108-11. Date of Electronic Publication: 2010 Jun 09. - Publication Year :
- 2010
-
Abstract
- Synthesis of the marine natural products motualevic acids A, E, and analogs in which modifications have been made to the omega-brominated lipid (E)-14,14-dibromotetra-deca-2,13-dienoic acid or amino acid unit are reported, together with antimicrobial activities against Staphylococcus aureus, methicillin-resistant S. aureus, Enterococcus faecium, and vancomycin-resistant Enterococcus.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Anti-Bacterial Agents chemistry
Enterococcus drug effects
Enterococcus faecium drug effects
Fatty Acids, Unsaturated chemistry
Glycine chemical synthesis
Glycine chemistry
Glycine pharmacology
Methicillin-Resistant Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Structure-Activity Relationship
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Fatty Acids, Unsaturated chemical synthesis
Fatty Acids, Unsaturated pharmacology
Glycine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20538459
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.05.073