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The potential value of Clostridium difficile vaccine: an economic computer simulation model.
- Source :
-
Vaccine [Vaccine] 2010 Jul 19; Vol. 28 (32), pp. 5245-53. Date of Electronic Publication: 2010 Jun 10. - Publication Year :
- 2010
-
Abstract
- Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.<br /> ((c) 2010 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 28
- Issue :
- 32
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 20541582
- Full Text :
- https://doi.org/10.1016/j.vaccine.2010.05.062