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Results of surgical resection for patients with large cell carcinoma of the lung.
- Source :
-
International journal of surgery (London, England) [Int J Surg] 2010; Vol. 8 (5), pp. 391-4. Date of Electronic Publication: 2010 Jun 12. - Publication Year :
- 2010
-
Abstract
- Purpose: The clinical features of large cell carcinoma (LCC) of the lung have remained unclear due to the low incidence of the disease. This study investigated the clinicopathological features and the surgical outcome in patients with LCC.<br />Subjects: This study clinicopathologically evaluated 975 patients who had undergone a resection for non-small cell carcinoma between 1994 and 2007. There were 57 (5.8%) patients with LCC among them.<br />Results: The LCC patients included 49 males and 8 females and included 9 patients with large cell neuroendocrine carcinoma. All patients excluding 1 had a smoking habit. The mean smoking pack-year index was 49.9 in the patients with LCC, 27.1 in 625 patients with adenocarcinoma, and 52.5 in 266 patients with squamous cell carcinoma, and this was significantly higher in the patients with LCC than in those with adenocarcinoma. The mean tumor diameter was 38 mm for LCC, 28 mm for adenocarcinoma, and 39 mm for squamous cell carcinoma. The pathological stage was IA in 11 patients, IB in 11, II in 12, IIIA in 16, IIIB in 5, and IV in 2. The post-operative 5-year survival rate was 60.5% for LCC, 64.3% for large cell neuroendocrine carcinoma, 67.0% for adenocarcinoma, and 50.1% for squamous cell carcinoma.<br />Conclusion: The tumor diameter was significantly larger for LCC than for adenocarcinoma at the time of diagnosis. The proportion of smokers and the smoking pack-year index in patients with LCC were significantly higher than those of adenocarcinoma. The surgical results were similar between LCC and other non-small cell lung carcinomas.<br /> (Copyright 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Bronchoscopy
Carcinoma, Large Cell diagnosis
Carcinoma, Large Cell mortality
Diagnosis, Differential
Female
Follow-Up Studies
Humans
Japan epidemiology
Lung Neoplasms diagnosis
Lung Neoplasms mortality
Male
Middle Aged
Neoplasm Staging
Retrospective Studies
Survival Rate trends
Tomography, X-Ray Computed
Treatment Outcome
Carcinoma, Large Cell surgery
Lung Neoplasms surgery
Pneumonectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1743-9159
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of surgery (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 20547250
- Full Text :
- https://doi.org/10.1016/j.ijsu.2010.06.003