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Cholangiocarcinoma in Italy: A national survey on clinical characteristics, diagnostic modalities and treatment. Results from the "Cholangiocarcinoma" committee of the Italian Association for the Study of Liver disease.
- Source :
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Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2011 Jan; Vol. 43 (1), pp. 60-5. Date of Electronic Publication: 2010 Jun 26. - Publication Year :
- 2011
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Abstract
- Background: Very few studies assessed cholangiocarcinoma clinical characteristics.<br />Aim: To evaluate the clinical characteristics of intra-hepatic (IH) and extra-hepatic (EH)-CCA.<br />Methods: We performed a national survey based on a questionnaire.<br />Results: 218 cholangiocarcinomas were observed (47% EH-CCA, 53% IH-CCA) with an age at the diagnosis higher for EH-CCA. Coexistence of cirrhosis or viral cirrhosis was more frequent in IH-CCA than EH-CCA. An incidental asymptomatic presentation occurred in 28% of IH-CCA vs 4% EH-CCA whilst, 74% EH-CCA vs 28% IH-CCA presented with jaundice. 91% of IH-CCA presented as a single intra-hepatic mass, whilst 50% of EH-CCA was peri-hilar. In the diagnostic work-up, 70% of all cholangiocarcinoma cases received at least 3 different imaging procedures. Tissue-proven diagnosis was obtained in 80% cholangiocarcinoma. Open surgery with curative intent was performed in 45% of IH-CCA and 29% EH-CCA. 18% IH-CCA vs 4% EH-CCA did not received treatment.<br />Conclusions: In Italy IH-CCA is managed as frequently as EH-CCA. In comparison to EH-CCA, IH-CCA occurs at younger age and is more frequently associated with cirrhosis and with an incidental asymptomatic presentation. In contrast, most EH-CCAs are jaundiced at the diagnosis. Cholangiocarcinoma diagnostic management is cost- and time-consuming with curative surgical treatment applicable more frequently in IH-CCA.<br /> (Copyright © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Abdominal Pain etiology
Aged
Bile Duct Neoplasms complications
Bile Duct Neoplasms pathology
Bile Duct Neoplasms surgery
Bile Ducts, Extrahepatic diagnostic imaging
Bile Ducts, Intrahepatic diagnostic imaging
Cholangiocarcinoma complications
Cholangiocarcinoma pathology
Cholangiocarcinoma surgery
Cholangiopancreatography, Endoscopic Retrograde
Cholangiopancreatography, Magnetic Resonance
Data Collection
Diarrhea etiology
Fatigue etiology
Female
Hepatitis C complications
Humans
Italy
Jaundice etiology
Liver Cirrhosis complications
Male
Middle Aged
Nausea etiology
Tomography, X-Ray Computed
Ultrasonography
Vomiting etiology
Weight Loss
Bile Duct Neoplasms diagnosis
Bile Ducts, Extrahepatic pathology
Bile Ducts, Intrahepatic pathology
Cholangiocarcinoma diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 20580332
- Full Text :
- https://doi.org/10.1016/j.dld.2010.05.002