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Sequence-dependent hematologic side effects of topotecan and cisplatin in persistent or recurrent cervical cancer.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2010 Oct; Vol. 119 (1), pp. 87-91. Date of Electronic Publication: 2010 Jun 26. - Publication Year :
- 2010
-
Abstract
- Objective: This retrospective study evaluates the efficacy and toxicity of topotecan, followed by cisplatin, in patients with persistent or recurrent cervical cancer.<br />Methods: Twenty-four patients were included in the study. Ninety-two cycles of chemotherapy were administered during the study period. Topotecan (0.75 mg/m(2)) was administered as a 30-minute infusion on 3 consecutive days, and cisplatin was given intravenously at a dose of 50 mg/m(2) over 1h on day 3 of every third week.<br />Results: The median number of cycles administered was 3, with a range of 1-8 cycles per patient. There were 4 (16.7%) complete responses, 3 (12.5%) partial responses, and 5 (20.8%) stable disease. All of the patients with a complete response had received palliative radiation or surgery for pain or an isolated solitary recurrence prior to chemotherapy. There were no treatment delays of >7 days per cycle due to hematologic toxicity. There were 59 days of delay (average, 0.6 days per cycle) in 21 of 92 (22.8%) cycles and two episodes of dose reduction (cisplatin, 50% reduction) in 2 patients due to low creatinine clearance (30-60 mL/min). Overall, grade 3/4 anemia, thrombocytopenia, and neutropenia were experienced in 13.1%, 1.1%, and 18.5% of the courses, or 33.4%, 4.2%, and 45.8% of the patients, respectively.<br />Conclusion: Combination chemotherapy, consisting of topotecan on days 1-3 and cisplatin on day 3, showed a relatively low rate of hematologic toxicity, as compared with the regimen of topotecan on days 1-3 and cisplatin on day 1, as used in previous studies.<br /> (Copyright © 2010. Published by Elsevier Inc.)
- Subjects :
- Adult
Aged
Cisplatin administration & dosage
Cisplatin adverse effects
Female
Humans
Middle Aged
Neoplasm Recurrence, Local blood
Retrospective Studies
Topotecan administration & dosage
Topotecan adverse effects
Uterine Cervical Neoplasms blood
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Antineoplastic Combined Chemotherapy Protocols adverse effects
Hematologic Diseases chemically induced
Neoplasm Recurrence, Local drug therapy
Uterine Cervical Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 119
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20580417
- Full Text :
- https://doi.org/10.1016/j.ygyno.2010.05.030