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A systematic review of aripiprazole--dose, plasma concentration, receptor occupancy, and response: implications for therapeutic drug monitoring.
- Source :
-
The Journal of clinical psychiatry [J Clin Psychiatry] 2010 Nov; Vol. 71 (11), pp. 1447-56. Date of Electronic Publication: 2010 Jun 01. - Publication Year :
- 2010
-
Abstract
- Objective: To evaluate relationships between aripiprazole dose, plasma level, pharmacologic activity, and clinical outcome in order to evaluate the potential for therapeutic drug monitoring.<br />Data Sources: In August 2008, we searched Embase, MEDLINE, and PubMed databases using the keywords aripiprazole, plasma levels, plasma concentration, and therapeutic drug monitoring.<br />Study Selection: Twenty-one reports were retrieved. Eight studies investigating the relationship between blood concentrations of aripiprazole and dose, dopamine D(2)/D(3) occupancy, and/or outcome and adverse effects were then selected.<br />Data Extraction: All data concerning plasma or serum concentrations of aripiprazole were included if concentrations were reported in relation to a dose, dopamine occupancy, or clinical outcome. Those reports solely investigating drug interactions were not included.<br />Data Synthesis: A strong correlation exists between aripiprazole dose and plasma concentration. Positron emission tomography analyses suggest that there are significant relationships between dopamine receptor occupancy and both aripiprazole dose and blood concentration. Dopamine receptor occupancy appears to reach a plateau at doses above 10 mg, supporting the observation found in dose-response studies that 10 mg/d is the optimal dose for aripiprazole.<br />Conclusions: The dose range for aripiprazole is well defined, and it reliably predicts plasma level, dopamine receptor occupancy, and clinical response. Plasma level variation appears to have minimal impact on clinical response, but it may predict some adverse effects. A putative target plasma level range of between 150 and 210 ng/mL is suggested. Therapeutic drug monitoring has limited value in the clinical use of aripiprazole, but it may be useful in assuring adherence and optimizing response in individuals.<br /> (© Copyright 2010 Physicians Postgraduate Press, Inc.)
- Subjects :
- Antipsychotic Agents blood
Antipsychotic Agents therapeutic use
Aripiprazole
Dose-Response Relationship, Drug
Drug Monitoring
Humans
Piperazines blood
Piperazines therapeutic use
Positron-Emission Tomography
Psychotic Disorders drug therapy
Quinolones blood
Quinolones therapeutic use
Receptors, Dopamine drug effects
Receptors, Dopamine metabolism
Treatment Outcome
Antipsychotic Agents administration & dosage
Piperazines administration & dosage
Quinolones administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1555-2101
- Volume :
- 71
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of clinical psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 20584524
- Full Text :
- https://doi.org/10.4088/JCP.09r05060gre