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Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Aug 01; Vol. 20 (15), pp. 4491-5. Date of Electronic Publication: 2010 Jun 10. - Publication Year :
- 2010
-
Abstract
- A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several were found to have potent activity in vitro and in vivo.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Cell Line, Tumor
Drug Design
Humans
Male
Nitriles chemical synthesis
Nitriles therapeutic use
Prostatic Neoplasms drug therapy
Receptors, Androgen metabolism
Structure-Activity Relationship
Antineoplastic Agents chemical synthesis
Nitriles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20584610
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.06.034