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Is it necessary to perform prophylactic cholecystectomy for asymptomatic subjects with gallbladder polyps and gallstones?
- Source :
-
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2010 Jun; Vol. 25 (6), pp. 1099-104. - Publication Year :
- 2010
-
Abstract
- Background and Aims: The purpose of the present study was to determine the clinical characteristics of subjects with gallbladder polyps and cholelithiasis compared with those with gallbladder polyps only.<br />Methods: Between August 1999 and December 2005, 176 subjects with gallbladder polyps and cholelithiasis (study group) by transabdominal ultrasonography performed during a medical check-up at our institution were recruited and compared with a control group of 185 subjects who had gallbladder polyps only.<br />Results: No significant difference in the mean interval change (delta) of polyp size during the follow-up period between the study and control groups (0.85 +/- 1.39 mm vs 0.84 +/- 1.58 mm, respectively, P = 0.927) was noted. A significantly higher proportion (9/176 [5.1%]) of examinees in the study group had attacks of acute cholecystitis compared with the control group (1/185 [0.5%], P < 0.01). By multivariate logistic regression analysis, gallbladder wall thickening on initial ultrasonography (odds ratio, 13.7; 95% confidence interval, 1.1-178.0; P = 0.046) and the interval increase in the size of the gallbladder polyps (odds ratio, 14.7; 95% confidence interval, 1.7-126.9; P = 0.014) were independent risk factors for cholecystectomy. No gallbladder cancer occurred during the follow-up period.<br />Conclusions: There was no significant difference in delta polyp size between the examinees with gallbladder polyps and cholelithiasis and those with gallbladder polyps only. Hence, a small proportion of subjects with gallbladder polyps and cholelithiasis, such as those with thickened gallbladder walls and an interval increase in the size of the gallbladder polyps are candidates for prophylactic cholecytectomy.
- Subjects :
- Adult
Confidence Intervals
Denmark epidemiology
Female
Follow-Up Studies
Gallbladder Neoplasms diagnosis
Gallbladder Neoplasms epidemiology
Gallstones diagnosis
Gallstones epidemiology
Humans
Male
Odds Ratio
Polyps diagnosis
Polyps epidemiology
Prevalence
Retrospective Studies
Cholecystectomy methods
Decision Making
Gallbladder Neoplasms prevention & control
Gallstones prevention & control
Polyps prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1746
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 20594225
- Full Text :
- https://doi.org/10.1111/j.1440-1746.2010.06288.x