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Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2010 Aug 15; Vol. 202 (4), pp. 524-32. - Publication Year :
- 2010
-
Abstract
- Tuberculous pleurisy allows the study of specific cells at the site of Mycobacterium tuberculosis infection. Among pleural lymphocytes, natural killer (NK) cells are a major source of interferon gamma (IFN-gamma), and their functions are regulated by activating and inhibitory receptors. Programmed death-1 (PD-1), programmed death ligand 1 (PD-L1), and programmed death ligand 2 (PD-L2) are recognized inhibitory receptors in adaptive immunity, but their role during innate immunity remains poorly understood. We investigated the PD-1:PD-L1/PD-L2 pathway on NK cell effector functions in peripheral blood and pleural fluid from patients with tuberculosis. M. tuberculosis stimulation significantly up-regulated PD-1, PD-L1, and PD-L2 levels on NK cells. Interestingly, a direct correlation between PD-1 and IFN-gamma expression on NK cells was observed. Moreover, blockade of the PD-1 pathway markedly augmented lytic degranulation and IFN-gamma production of NK cells against M. tuberculosis. Furthermore, PD-1(+) NK cells displayed a diminished IFN-gamma mean fluorescence intensity, denoting the relevance of PD-1 on IFN-gamma regulation. Together, we described a novel inhibitory role played by PD-1:PD-L interactions in innate immunity in tuberculosis.
- Subjects :
- Adult
B7-H1 Antigen
Blood immunology
Gene Expression Profiling
Humans
Intercellular Signaling Peptides and Proteins immunology
Interferon-gamma antagonists & inhibitors
Interferon-gamma metabolism
Killer Cells, Natural immunology
Pleura immunology
Programmed Cell Death 1 Ligand 2 Protein
Programmed Cell Death 1 Receptor
Up-Regulation
Antigens, CD immunology
Apoptosis
Apoptosis Regulatory Proteins immunology
Immunity, Innate
Mycobacterium tuberculosis immunology
Tuberculosis immunology
Tuberculosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 202
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 20617899
- Full Text :
- https://doi.org/10.1086/654932