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GCF and serum myeloperoxidase and matrix metalloproteinase-13 levels in renal transplant patients.
- Source :
-
Archives of oral biology [Arch Oral Biol] 2010 Oct; Vol. 55 (10), pp. 719-27. Date of Electronic Publication: 2010 Jul 15. - Publication Year :
- 2010
-
Abstract
- Aim: The rationale of this study was to address whether local or systemic changes reflect proteolytic (matrix metalloproteinase-13) or oxidative (myeloperoxidase) stress in renal transplant patients receiving cyclosporine-A (CsA) and having gingival overgrowth (GO), in patients receiving CsA therapy and having no GO and patients receiving tacrolimus therapy.<br />Material and Methods: Gingival crevicular fluid (GCF) samples were collected from sites with (GO+) and without GO (GO-) in CsA patients having GO; GO- sites in CsA patients having no GO; sites from tacrolimus, gingivitis and healthy subjects. GCF and serum myeloperoxidase (MPO) and matrix metalloproteinase-13 (MMP-13) levels were determined by ELISA.<br />Results: GO+ sites in CsA patients having GO had elevated GCF MPO levels than those of CsA patients having no GO, tacrolimus and healthy subjects (p<0.005), but comparable to those of gingivitis. GCF MPO levels were higher in GO+ compared to GO- sites in CsA patients having GO (p<0.05). Patient groups had similar, but higher GCF MMP-13 levels than healthy group.<br />Conclusions: These results show that CsA and tacrolimus therapy have not a significant effect on GCF MPO and MMP-13 levels, and gingival inflammation seems to be the main reason for their elevations.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Case-Control Studies
Cyclosporine blood
Enzyme-Linked Immunosorbent Assay
Female
Gingival Overgrowth blood
Gingival Overgrowth enzymology
Humans
Immunosuppressive Agents blood
Male
Matrix Metalloproteinase 13 analysis
Matrix Metalloproteinase 13 blood
Middle Aged
Normal Distribution
Peroxidase analysis
Peroxidase blood
Statistics, Nonparametric
Tacrolimus blood
Tacrolimus therapeutic use
Young Adult
Cyclosporine adverse effects
Gingival Crevicular Fluid enzymology
Gingival Overgrowth chemically induced
Gingivitis enzymology
Immunosuppressive Agents adverse effects
Kidney Transplantation
Matrix Metalloproteinase 13 metabolism
Peroxidase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1506
- Volume :
- 55
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of oral biology
- Publication Type :
- Academic Journal
- Accession number :
- 20637451
- Full Text :
- https://doi.org/10.1016/j.archoralbio.2010.06.011