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Impact of diagnostic ureteroscopy on intravesical recurrence and survival in patients with urothelial carcinoma of the upper urinary tract.
- Source :
-
The Journal of urology [J Urol] 2010 Sep; Vol. 184 (3), pp. 883-7. - Publication Year :
- 2010
-
Abstract
- Purpose: We determined whether diagnostic ureteroscopy for upper urinary tract cancer affects intravesical recurrence and cancer specific mortality.<br />Materials and Methods: In a retrospective, multi-institutional study we evaluated 208 patients undergoing nephroureterectomy for upper urinary tract cancer who had no perioperative systemic chemotherapy, history of invasive bladder cancer, distant metastasis or incomplete followup data. Of these 208 patients 55 who composed the study group underwent diagnostic ureteroscopy before nephroureterectomy while 153 serving as controls did not. We analyzed intravesical recurrence and cancer specific survival using the Kaplan-Meier method with the log rank test used to assess significance.<br />Results: There was no significant difference between the 2 groups in patient characteristics or upper urinary tract cancer stage and grade while followup, and the proportion of multiple tumors and lymphovascular invasion positive tumors were significantly greater in controls. The 2-year bladder recurrence-free survival rate was 60.0% in the study group and 58.7% in controls. There was no significant difference in the intravesical recurrence rate between the 2 groups (log rank test p = 0.972). Estimated Kaplan-Meier cancer specific survival was 88.3% and 78.1% at 5 years in the study and control groups, respectively (log rank test p = 0.0687).<br />Conclusions: Diagnostic ureteroscopy did not affect intravesical recurrence or cancer specific survival in patients with upper urinary tract cancer undergoing nephroureterectomy.<br /> (2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Transitional Cell epidemiology
Female
Humans
Male
Middle Aged
Retrospective Studies
Survival Rate
Urinary Bladder Neoplasms epidemiology
Carcinoma, Transitional Cell diagnosis
Carcinoma, Transitional Cell mortality
Kidney Neoplasms diagnosis
Kidney Neoplasms surgery
Kidney Pelvis
Neoplasm Recurrence, Local diagnosis
Neoplasm Recurrence, Local mortality
Nephrectomy
Ureteral Neoplasms diagnosis
Ureteral Neoplasms surgery
Ureteroscopy
Urinary Bladder Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3792
- Volume :
- 184
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 20643446
- Full Text :
- https://doi.org/10.1016/j.juro.2010.05.027