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Anxiolytic-like and sedative actions of Rollinia mucosa: possible involvement of the GABA/benzodiazepine receptor complex.
- Source :
-
Pharmaceutical biology [Pharm Biol] 2010 Jan; Vol. 48 (1), pp. 70-5. - Publication Year :
- 2010
-
Abstract
- This study evaluated possible CNS effects of a hexane extract of leaves from Rollinia mucosa (Jacq.) Baill. (Annonaceae). This plant extract induced anxiolytic-like actions similar to those induced by diazepam in the avoidance exploratory behavior paradigm. Its significant activity was shown at doses from 1.62 to 6.25 mg/kg. It also enhanced pentobarbital-induced hypnosis time, and at high doses produced motor coordination impairment. The benzodiazepine (BDZ) receptor binding, evaluated by in vitro autoradiography following a single administration of R. mucosa, revealed that this plant extract reduced BDZ binding in the hippocampus (29%), amygdala (26%), and temporal cortex of mice (36%). In conclusion, the present findings support the proposal that R. mucosa may induce central nervous system (CNS) depressant effects, presumably through an interaction with the GABA/benzodiazepine receptor complex.
- Subjects :
- Animals
Anti-Anxiety Agents isolation & purification
Anti-Anxiety Agents therapeutic use
Anxiety drug therapy
Dose-Response Relationship, Drug
Drug Synergism
Exploratory Behavior drug effects
Exploratory Behavior physiology
Hypnotics and Sedatives isolation & purification
Hypnotics and Sedatives therapeutic use
Male
Mice
Motor Activity drug effects
Motor Activity physiology
Pentobarbital pharmacology
Pentobarbital therapeutic use
Plant Extracts isolation & purification
Plant Extracts therapeutic use
Anti-Anxiety Agents pharmacology
Hypnotics and Sedatives pharmacology
Plant Extracts pharmacology
Receptors, GABA physiology
Receptors, GABA-A physiology
Rollinia
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5116
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmaceutical biology
- Publication Type :
- Academic Journal
- Accession number :
- 20645758
- Full Text :
- https://doi.org/10.3109/13880200903046153