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[A case report of bi-weekly docetaxel and S-1 combination chemotherapy for gastric cancer with multiple liver metastases and esophageal invasion].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2010 Jul; Vol. 37 (7), pp. 1353-6. - Publication Year :
- 2010
-
Abstract
- A 61-year-old man with the chief complaint of pressure with swallowing was referred to our hospital with type 3 cardiac gastric cancer. Gastrofiberscope showed type 3 cardiac cancer with esophageal invasion. On the abdominal computed tomography, there was evidence of lymph node swelling in the lesser curvature and multiple liver metastases. Blood tumor markers were elevated: CEA 200 ng/mL, CA19-9 2,490 U/mL. He was diagnosed as unresectable advanced gastric cancer UE-circ, type-3, c-T3N2H1P0M1, Stage IV. A biopsy revealed adenocarcinoma (tub2-por1). We started bi-weekly docetaxel and S-1 combination chemotherapy(DOC 40 mg/m2 day 1, 14, S-180 mg/m2 day 1-7, 14-21). After completion of the first course of this combination therapy, his feeling of pressure was relieved and CT showed reduction of multiple liver lesions and lymph node metastases, indicating partial response. No regrowth was seen for 7 courses of the therapy. Regarding toxicity, grade 2 nausea and grade 1 nail pain were observed. After 7 courses, because of serum CEA elevation, bi-weekly CPT-11/CDDP therapy (CPT-11 60 mg/m2, CDDP 30 mg/m2) was administered followed by weekly PTX therapy (65 mg/m2 day 1, 7, 14; total of 4 weeks). To date, 17 months after administration of chemotherapy, he has been treated on an outpatient basis. Biweekly DOC/S-1 therapy can be novel antitumor therapy which can be conducted safely in an outpatient setting for advanced gastric cancer.
- Subjects :
- Docetaxel
Drug Combinations
Esophageal Neoplasms diagnostic imaging
Esophageal Neoplasms pathology
Esophageal Neoplasms secondary
Esophagoscopy
Gastroscopy
Humans
Liver Neoplasms diagnostic imaging
Liver Neoplasms secondary
Male
Middle Aged
Neoplasm Invasiveness
Oxonic Acid administration & dosage
Stomach Neoplasms diagnostic imaging
Stomach Neoplasms pathology
Taxoids administration & dosage
Tegafur administration & dosage
Tomography, X-Ray Computed
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Esophageal Neoplasms drug therapy
Liver Neoplasms drug therapy
Oxonic Acid therapeutic use
Stomach Neoplasms drug therapy
Taxoids therapeutic use
Tegafur therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 37
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 20647726