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Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Sep 01; Vol. 20 (17), pp. 5203-6. Date of Electronic Publication: 2010 Jul 06. - Publication Year :
- 2010
-
Abstract
- N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20655209
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.07.001