Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

Authors :: Giraud F
Marchand P
Carbonnelle D
Sartor M
Lang F
Duflos M
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Sep 01; Vol. 20 (17), pp. 5203-6. Date of Electronic Publication: 2010 Jul 06.
Publication Year :: 2010
Abstract: N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.<br /> (Copyright 2010 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Hypersensitivity, Delayed
In Vitro Techniques
Indoles chemistry
Inhibitory Concentration 50
Mice
Amides chemical synthesis
Amides pharmacology
Immunosuppressive Agents chemical synthesis
Immunosuppressive Agents pharmacology

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