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Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors.
- Source :
-
Nutrition and cancer [Nutr Cancer] 2010; Vol. 62 (6), pp. 734-42. - Publication Year :
- 2010
-
Abstract
- The Kashmir Valley has an elevated incidence rate of esophageal cancer (EC). Several environmental and genetic factors have been suspected for development of EC. A case-control study was performed in 135 EC patients and 195 healthy controls to analyze association of polymorphisms in glutathione S-transferase (GST) mu (GSTM1), GST theta (GSTT1), GST pi (GSTP1), GSTM3, Cytochrome P450 (CYP)1A1, and CYP2E1 genes with susceptibility to EC as well as their interaction with environmental factors such as smoking and high consumption of salted tea in Kashmir valley. All subjects were genotyped through polymerase chain reaction restriction fragment length polymorphism. Data was statistically analyzed using the chi-square test and logistic regression model. Results showed that GSTP1313 val/val and CYP2E1c1c2 genotypes imparted risk for esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma [EADC; odds ratio (OR) = 3.24, 95% confidence interval (CI) = 1.30-8.05; OR = 4.20, 95% CI = 1.65-10.70], respectively. GSTM3AB genotype/B allele was found to be associated with low risk for EC. Tobacco smoking through hukka (water pipe) and consumption of salted tea itself were high risk factors for developing EC (OR = 21.44, 95% CI = 11.63-39.54; OR = 14.86, 95% CI = 8.41-26.24), and the risks were modulated through the interaction of GSTM3AB, GSTP1val/val genotypes. In conclusion, GSTP1val/val and CYP2E1c1c2 genotypes/c2 allele increased the risk of ESCC and EADC, respectively, in the Kashmiri population; whereas GSTM3AB genotype imparted lower risk for both ESCC and EADC.
- Subjects :
- Adult
Aged
Case-Control Studies
Cytochrome P-450 CYP1A1 genetics
Cytochrome P-450 CYP2E1 genetics
Environment
Esophageal Neoplasms genetics
Female
Genotype
Glutathione S-Transferase pi genetics
Glutathione Transferase genetics
Humans
India
Male
Middle Aged
Esophageal Neoplasms etiology
Polymorphism, Genetic
Xenobiotics metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-7914
- Volume :
- 62
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nutrition and cancer
- Publication Type :
- Academic Journal
- Accession number :
- 20661821
- Full Text :
- https://doi.org/10.1080/01635581003605904