[The characteristics of the development in houseflies of resistance to synergized and nonsynergized permethrin].

Peculiarities of the development of room fly resistance during selection with permetrine have been studied in the laboratory conditions. A strain possessing a 50-fold level of resistance to permetrine has been obtained. A range of cross-resistance of this strain to insecticides of various chemical classes has been determined. It has been established that the basic mechanism regulating resistance to permetrine is an increase in cytochrome P-450 monooxygenases. Resistance can be overcome using a mixture consisting of permetrine and monooxygenase inhibitor piperonylbutoxide. The mixture retains its efficacy in almost 20 generations; later on the development of resistance to the mixture is accompanied by an increase in the level of resistance to nonsynergized piretroides and other preparations.