Back to Search
Start Over
Reproducibility of [11C]choline-positron emission tomography and effect of trastuzumab.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2010 Aug 15; Vol. 16 (16), pp. 4236-45. Date of Electronic Publication: 2010 Aug 03. - Publication Year :
- 2010
-
Abstract
- Purpose: This study sought to evaluate the reproducibility of [(11)C]choline-positron emission tomography and the effect of trastuzumab in breast cancer.<br />Experimental Design: Twenty-one patients with newly diagnosed and recurrent breast cancer stage II-IV had a baseline dynamic [(11)C]choline-PET scan, 10 patients had a second [(11)C]choline-PET scan to examine reproducibility, and 6 patients had a second scan within a month after trastuzumab. Analysis of [(11)C]choline uptake was measured as the semiquantitative standardized uptake value at 30 and 60 minutes (SUV(30) and SUV(60)), and quantitatively as the net irreversible retention of the radiotracer at steady-state (Ki) and plasma to tissue exchange at 60 minutes (IRF60min).<br />Results: Breast tumor lesions in all patients were visualized by [(11)C]choline PET. The difference in tumor versus normal tissue uptake was significant for SUV(30), SUV(60), Ki, and IRF60 minutes (Wilcoxon P < 0.0001). At 60 minutes postinjection, 15.1 +/- 2.16% of plasma radioactivity was due to unmetabolized [(11)C]choline radioactivity. [(11)C]Choline uptake was reproducible in breast tumor lesions (r(2) = 0.9 for SUV, 0.9 for Ki, and 0.8 for IRF60). Early responses to trastuzumab measured by [(11)C]choline-PET were significant in three lesions occurring in two patients who responded clinically.<br />Conclusions: [(11)C]Choline-PET uptake variables can be reproducibly assessed. Initial studies show that trastuzumab decreases [(11)C]choline uptake.
- Subjects :
- Adult
Aged
Antibodies, Monoclonal, Humanized
Breast Neoplasms drug therapy
Breast Neoplasms pathology
Carbon Radioisotopes pharmacokinetics
Female
Humans
Image Interpretation, Computer-Assisted
Middle Aged
Neoplasm Staging
Reproducibility of Results
Trastuzumab
Antibodies, Monoclonal therapeutic use
Antineoplastic Agents therapeutic use
Breast Neoplasms diagnostic imaging
Choline pharmacokinetics
Positron-Emission Tomography methods
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1557-3265
- Volume :
- 16
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 20682702
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-10-0468