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Family history of Alzheimer's disease and hippocampal structure in healthy people.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 2010 Nov; Vol. 167 (11), pp. 1399-406. Date of Electronic Publication: 2010 Aug 04. - Publication Year :
- 2010
-
Abstract
- Objective: Structural brain changes appear years before the onset of Alzheimer's disease, the leading cause of dementia late in life. Determining risk factors for such presymptomatic brain changes may assist in identifying candidates for future prevention treatment trials. In addition to the e4 allele of the apolipoprotein E gene (APOE-4), the major known genetic risk factor, a family history of Alzheimer's disease also increases the risk to develop the disease, reflecting yet unidentified genetic and, perhaps, nongenetic risks. The authors investigated the influence of APOE-4 genotype and family history risks on cortical thickness in medial temporal lobe subregions among volunteers without cognitive impairment.<br />Method: High-resolution magnetic resonance imaging (MRI) and a cortical unfolding method were performed on 26 subjects (APOE-4 carriers: N=13; noncarriers: N=13) with at least one first-degree relative with Alzheimer's disease and 25 subjects (APOE-4 carriers: N=12; noncarriers: N=13) without this risk factor. All subjects (mean age: 62.3 years [SD=10.7]; range=38-86 years) were cognitively healthy.<br />Results: Family history of Alzheimer's disease and APOE-4 status were associated with a thinner cortex in the entorhinal region, subiculum, and adjacent medial temporal lobe subfields. Although these associations were additive, family history of Alzheimer's disease explained a greater proportion of the unique variance in cortical thickness than APOE-4 carrier status.<br />Conclusions: APOE-4 carrier status and family history of Alzheimer's disease are independently associated with and contribute additively to hippocampal cortical thinning.
- Subjects :
- Adult
Aged
Aged, 80 and over
Alzheimer Disease diagnosis
Alzheimer Disease pathology
Entorhinal Cortex pathology
Female
Genetic Carrier Screening
Humans
Male
Middle Aged
Reference Values
Risk Factors
Temporal Lobe pathology
Alzheimer Disease genetics
Apolipoprotein E4 genetics
Cerebral Cortex pathology
Genotype
Hippocampus pathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7228
- Volume :
- 167
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 20686185
- Full Text :
- https://doi.org/10.1176/appi.ajp.2010.09111575