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Plasma glucose and not hemoglobin or renal function predicts mortality in patients with STEMI complicated with cardiogenic shock.
- Source :
-
Journal of cardiovascular medicine (Hagerstown, Md.) [J Cardiovasc Med (Hagerstown)] 2010 Nov; Vol. 11 (11), pp. 827-31. - Publication Year :
- 2010
-
Abstract
- Objective: To assess the predictive value of three biomarkers for mortality in ST-segment elevation myocardial infarction (STEMI) with cardiogenic shock.<br />Background: STEMI complicated by cardiogenic shock accounts for the majority of STEMI related deaths. Patients with STEMI and hyperglycemia, anemia or kidney dysfunction on admission have a poor prognosis. As data on the combination of those three established predictors of mortality are sparse in STEMI with cardiogenic shock, the objective of the current study was to investigate their predictive value in STEMI patients with cardiogenic shock.<br />Methods and Results: Between 1997 and 2005, a total of 3038 patients presented with STEMI and were treated with percutaneous coronary intervention (PCI). On admission 292 patients presented with cardiogenic shock. Glucose, hemoglobin and creatinine clearance were available in 183 out of 292 patients. Overall 1-year mortality was 34%. In multivariate logistic regression analysis, only glucose remained a strong independent predictor for mortality. The odds for mortality increased by 11% for each 1 mmol/l increase in glucose (OR 1.11, 95% CI 1.02-1.21, P = 0.013).<br />Conclusion: Hemoglobin and creatinine clearance bear no prognostic value. Only admission glucose levels strongly and independently predict 1-year mortality in STEMI patients with cardiogenic shock and treated with PCI.
- Subjects :
- Aged
Anemia blood
Anemia complications
Angioplasty, Balloon, Coronary mortality
Biomarkers blood
Chi-Square Distribution
Female
Humans
Hyperglycemia blood
Hyperglycemia complications
Kidney metabolism
Logistic Models
Male
Middle Aged
Myocardial Infarction blood
Myocardial Infarction complications
Myocardial Infarction physiopathology
Myocardial Infarction therapy
Netherlands
Odds Ratio
Patient Admission
Prospective Studies
Registries
Risk Assessment
Risk Factors
Shock, Cardiogenic blood
Shock, Cardiogenic etiology
Shock, Cardiogenic physiopathology
Time Factors
Treatment Outcome
Anemia mortality
Blood Glucose metabolism
Creatinine blood
Hemoglobins metabolism
Hyperglycemia mortality
Kidney physiopathology
Myocardial Infarction mortality
Shock, Cardiogenic mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1558-2035
- Volume :
- 11
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular medicine (Hagerstown, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 20686421
- Full Text :
- https://doi.org/10.2459/JCM.0b013e32833cdc6d