Back to Search
Start Over
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
- Source :
-
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2011 Jan; Vol. 21 (1), pp. 71-9. Date of Electronic Publication: 2010 Aug 10. - Publication Year :
- 2011
-
Abstract
- Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.<br /> (Copyright © 2010 Elsevier B.V. and ECNP. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-7862
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 20702067
- Full Text :
- https://doi.org/10.1016/j.euroneuro.2010.07.004