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Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.

Authors :
Behan AT
van den Hove DL
Mueller L
Jetten MJ
Steinbusch HW
Cotter DR
Prickaerts J
Source :
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2011 Jan; Vol. 21 (1), pp. 71-9. Date of Electronic Publication: 2010 Aug 10.
Publication Year :
2011

Abstract

Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.<br /> (Copyright © 2010 Elsevier B.V. and ECNP. All rights reserved.)

Details

Language :
English
ISSN :
1873-7862
Volume :
21
Issue :
1
Database :
MEDLINE
Journal :
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Publication Type :
Academic Journal
Accession number :
20702067
Full Text :
https://doi.org/10.1016/j.euroneuro.2010.07.004