Back to Search
Start Over
STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling.
- Source :
-
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2010 Nov; Vol. 46 (16), pp. 2996-3006. Date of Electronic Publication: 2010 Aug 13. - Publication Year :
- 2010
-
Abstract
- The principal Epstein-Barr virus (EBV) oncoprotein, latent membrane protein 1 (LMP1), has been suggested to contribute to the highly invasive nature of nasopharyngeal carcinoma (NPC). Signal transducer and activator of transcription 3 (STAT3) is a master transcriptional regulator in proliferation and apoptosis and is newly implicated in angiogenesis and invasiveness, which, in turn, are likely to contribute to the highly invasive character of NPC. The fundamental molecular mechanisms of LMP1-regulated STAT3 activation in NPC cell invasion have not been completely explored. Here, we showed that LMP1 signals the Janus kinase 3 (JAK3) and extracellular signal-regulated kinase 1/2 (ERK1/2) pathways upon the activation of STAT3 as well as STAT transactivation activity. LMP1 induces vascular endothelial growth factor (VEGF) expression via the JAK/STAT and mitogen-activated protein kinase (MAPK)/ERK signalling pathways. Induction of STAT3 by the human viral oncoprotein LMP1 may contribute to the invasion of NPC.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Blotting, Western
Cell Line, Tumor
Humans
Janus Kinase 3
Nasopharyngeal Neoplasms pathology
Neoplasm Invasiveness
RNA, Small Interfering metabolism
Transfection
Vascular Endothelial Growth Factors metabolism
Viral Matrix Proteins antagonists & inhibitors
Mitogen-Activated Protein Kinase 1 metabolism
Mitogen-Activated Protein Kinase 3 metabolism
Nasopharyngeal Neoplasms metabolism
STAT3 Transcription Factor metabolism
Vascular Endothelial Growth Factors biosynthesis
Viral Matrix Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0852
- Volume :
- 46
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Publication Type :
- Academic Journal
- Accession number :
- 20709526
- Full Text :
- https://doi.org/10.1016/j.ejca.2010.07.008