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Class III NSRH: oncological outcome in 170 cervical cancer patients.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2010 Nov; Vol. 119 (2), pp. 192-7. Date of Electronic Publication: 2010 Aug 16. - Publication Year :
- 2010
-
Abstract
- Objective: To analyze local recurrence rate (LRR), morbidities and oncologic outcome of class III nerve-sparing radical hysterectomy.<br />Patients and Methods: 170 consecutive class III NSRH cases were performed. Nineteen patients were addressed directly to surgery whilst neoadjuvant chemotherapy was administered in 151 patients. The majority of patients had SCC (75%). The median follow-up was 31 months.<br />Results: The mean age was 50 [27-78] years. Mean post-operative hospital stay was 7 [3-16] days. 2 intraoperative complications occurred. Operating time and blood loss was similar to the state-of-the-art of conventional radical hysterectomy. Overall G3-4 complication rate was 8.2 % (14/170). Early G3-4 complication rate was 3.5% (6/170). Late G3-4 complication rate was: 4.7%. (8/170). Positive pelvic nodes were noted in 31 patients (18.2%). Vagina and parametrial involvement were present in 38 (22%) and 27 (15.8%) patients, respectively. LRR was 10% (17/170). The sites of relapse were: 12 pelvic, 5 vaginal. There were 9 patients DOD. The 2-year and 5-year DFS rates were 89% and 81%, respectively. Univariate and multivariate analysis identified vagina involvement and postoperative treatment as significant prognostic factors.<br />Conclusions: The oncologic results of NSRH were similar to the state-of-the-art of conventional radical hysterectomy. Two years DFS in relation to FIGO stage of disease was 92.3, 89.2 and 86.1 % respectively for IB1, IB2, IIB comparable to literature data. The early and late complications rate related to autonomic injury was significantly lower. The nerve-sparing technique should be considered in all cervical cancer patients addressed to surgery.<br /> (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Chemotherapy, Adjuvant
Cohort Studies
Female
Humans
Hysterectomy adverse effects
Middle Aged
Morbidity
Neoadjuvant Therapy
Neoplasm Recurrence, Local pathology
Treatment Outcome
Uterine Cervical Neoplasms drug therapy
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms radiotherapy
Hysterectomy methods
Uterine Cervical Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 119
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 20719370
- Full Text :
- https://doi.org/10.1016/j.ygyno.2010.07.030