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Outpatient parenteral antimicrobial therapy: Recent developments and future prospects.
- Source :
-
Current opinion in investigational drugs (London, England : 2000) [Curr Opin Investig Drugs] 2010 Aug; Vol. 11 (8), pp. 929-39. - Publication Year :
- 2010
-
Abstract
- Patients with serious infections requiring parenteral antimicrobial therapy are usually hospitalized for treatment. For certain conditions, however, administration of parenteral antibiotics outside the hospital setting may be safe, efficacious, convenient for patients and cost-beneficial. Outpatient parenteral antimicrobial therapy (OPAT) was developed in the US initially and its use has expanded globally during the past three decades. A wide variety of infections are amenable to treatment by OPAT. Once-daily agents such as ceftriaxone or teicoplanin and, more recently, antimicrobials such as ertapenem or daptomycin have been used for OPAT. The use of higher doses and less-frequent dosing of existing agents is being explored, and exciting new developments include the emergence of agents with broader-spectrum activity against drug-resistant organisms and the use of antifungal agents in the OPAT setting. Future prospects in OPAT include the use of more recently launched drugs such as telavancin, as well as drugs in development, including dalbavancin (Durata Therapeutics Inc) and omadacycline (PTK-0796; Novartis AG/PARATEK Pharmaceuticals Inc). This review outlines recent developments in, and future prospects for, the antimicrobial agents used in OPAT.
- Subjects :
- Aminoglycosides administration & dosage
Aminoglycosides pharmacology
Aminoglycosides therapeutic use
Anti-Bacterial Agents pharmacology
Anti-Infective Agents therapeutic use
Daptomycin administration & dosage
Daptomycin pharmacology
Daptomycin therapeutic use
Dosage Forms
Ertapenem
Humans
Infusions, Parenteral
Lipoglycopeptides
Teicoplanin administration & dosage
Teicoplanin analogs & derivatives
Teicoplanin pharmacology
Teicoplanin therapeutic use
beta-Lactams administration & dosage
beta-Lactams pharmacology
beta-Lactams therapeutic use
Ambulatory Care
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Anti-Infective Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2040-3429
- Volume :
- 11
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Current opinion in investigational drugs (London, England : 2000)
- Publication Type :
- Academic Journal
- Accession number :
- 20721835