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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
- Source :
-
Nature genetics [Nat Genet] 2010 Sep; Vol. 42 (9), pp. 764-7. Date of Electronic Publication: 2010 Aug 22. - Publication Year :
- 2010
-
Abstract
- We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.
- Subjects :
- Adenocarcinoma ethnology
Asian People genetics
Carcinoma, Squamous Cell ethnology
Case-Control Studies
Esophageal Neoplasms ethnology
Female
Gene Frequency
Genetic Predisposition to Disease genetics
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Male
Stomach Neoplasms ethnology
Adenocarcinoma genetics
Carcinoma, Squamous Cell genetics
Chromosomes, Human, Pair 10
Esophageal Neoplasms genetics
Genetic Loci
Phosphoinositide Phospholipase C genetics
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 42
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 20729852
- Full Text :
- https://doi.org/10.1038/ng.649