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[Synthesis of gallic acid derivatives with L-thiazolidin-4-carboxylic acid and study on their antiradical and antitoxic activity].
- Source :
-
Bollettino chimico farmaceutico [Boll Chim Farm] 1990 Jun; Vol. 129 (6), pp. 226-9. - Publication Year :
- 1990
-
Abstract
- The authors report the synthesis of three new derivatives of gallic acid with L-thiazolidine-4-carboxylic acid. The new compounds were tested for radical scavenger activity against doxorubicin toxicity in mice and for antitoxic activity against acetaldehyde and formaldehyde toxicities in rats. Unlike the utilized standards, the new compounds show no activity.
- Subjects :
- Acetaldehyde antagonists & inhibitors
Acetaldehyde toxicity
Animals
Antidotes pharmacology
Doxorubicin antagonists & inhibitors
Doxorubicin toxicity
Formaldehyde antagonists & inhibitors
Formaldehyde toxicity
Gallic Acid chemical synthesis
Gallic Acid pharmacology
Male
Mice
Mice, Inbred Strains
Thiazoles chemical synthesis
Thiazolidines
Antidotes chemical synthesis
Free Radical Scavengers
Gallic Acid analogs & derivatives
Thiazoles pharmacology
Subjects
Details
- Language :
- Italian
- ISSN :
- 0006-6648
- Volume :
- 129
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bollettino chimico farmaceutico
- Publication Type :
- Academic Journal
- Accession number :
- 2073378