Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily.

Authors :: Wecksler SR
Stoll S
Iavarone AT
Imsand EM
Tran H
Britt RD
Klinman JP
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Oct 07; Vol. 46 (37), pp. 7031-3. Date of Electronic Publication: 2010 Aug 25.
Publication Year :: 2010
Abstract: pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S](+) clusters. This interaction redirects the role for PqqD in PQQ biosynthesis.

Subjects :: Bacterial Proteins metabolism
Free Radicals chemistry
Free Radicals metabolism
Klebsiella pneumoniae enzymology
PQQ Cofactor chemistry
S-Adenosylmethionine metabolism
Bacterial Proteins chemistry
PQQ Cofactor biosynthesis
S-Adenosylmethionine chemistry

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