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Natalizumab treatment reduces endothelial activity in MS patients.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2010 Oct 08; Vol. 227 (1-2), pp. 190-4. Date of Electronic Publication: 2010 Aug 23. - Publication Year :
- 2010
-
Abstract
- Vascular cell adhesion molecule-1 a ligand for leukocyte very late activating antigen-4 is a key player in leukocyte extravasation in MS lesions. Natalizumab a monoclonal antibody against VLA-4 blocks this interaction. VCAM-1 and its soluble form are up-regulated during endothelial activation in MS. We investigated the effect of Natalizumab on sVCAM-1 and VLA-4 on circulating leukocytes in MS patients. Natalizumab reduced levels of sVCAM-1 compared to controls (256 vs. 597 ng/mL). This effect was sustained and only reversed in patients with neutralizing antibodies against Natalizumab. Correspondingly Natalizumab diminished VLA-4 on leukocyte subsets. Our findings indicate that Natalizumab reduces transmigration not only by blocking VLA-4 but also by down-regulating VCAM-1.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Antibodies, Monoclonal, Humanized
Biomarkers blood
Endothelium, Vascular pathology
Follow-Up Studies
Humans
Integrin alpha4beta1 antagonists & inhibitors
Integrin alpha4beta1 immunology
Multiple Sclerosis pathology
Natalizumab
Vascular Cell Adhesion Molecule-1 biosynthesis
Vascular Cell Adhesion Molecule-1 immunology
Antibodies, Monoclonal therapeutic use
Cell Migration Inhibition immunology
Endothelium, Vascular immunology
Multiple Sclerosis drug therapy
Multiple Sclerosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 227
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 20739072
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2010.07.012