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Effect of caloric and non-caloric sweet reward solutions on thermal facial operant conditioning.
- Source :
-
Behavioural brain research [Behav Brain Res] 2011 Jan 20; Vol. 216 (2), pp. 723-5. Date of Electronic Publication: 2010 Aug 24. - Publication Year :
- 2011
-
Abstract
- Sweet solutions are commonly used in animal research to deliver drugs to test for addictive capacity and efficacy. In this study we compared the effects of a range of sucrose and saccharin concentrations on the performance of an operant assay. Our findings demonstrate that across a range of sucrose solutions some produce a success ratio which could mistakenly be labeled allodynic demonstrating the importance of choosing the correct reward solution.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Analysis of Variance
Animals
Dose-Response Relationship, Drug
Hot Temperature
Male
Nutritive Value
Pain Threshold physiology
Rats
Rats, Hairless
Rats, Sprague-Dawley
Saccharin pharmacology
Statistics, Nonparametric
Sucrose pharmacology
Thermosensing drug effects
Conditioning, Operant drug effects
Hyperalgesia chemically induced
Pain Threshold drug effects
Reward
Sweetening Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 216
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 20797411
- Full Text :
- https://doi.org/10.1016/j.bbr.2010.08.023