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Sub-lethal dosing of azaspiracid-1 in female NMRI mice.
- Source :
-
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2010 Dec; Vol. 56 (8), pp. 1419-25. Date of Electronic Publication: 2010 Aug 27. - Publication Year :
- 2010
-
Abstract
- The main aim of this study was to examine absorption and pathological effects of a single sub-lethal dose of the marine biotoxin azaspiracid-1 (AZA1) in mice after oral intubation. When the mice received AZA1 at doses of 100, 200 or 300 μg/kg body weight (b.w.), the toxin was absorbed dose-dependently. Highest concentrations after 24 h were detected in kidneys, spleen and lungs, followed by liver and heart. Only trace amounts were seen in the brain. After seven days, the toxin level had dropped significantly in all organs except for the kidneys. The amount of toxin absorbed was highest in the liver, followed by kidneys, lungs, spleen and heart and the total amount of toxin in the internal organs analysed after 24 h was estimated to be only about 2% of the total amount given for all three dose groups. Pathological changes were only detected in the upper part of the small intestine (duodenum), consisting of mild cellular detachment in the tips of the villi, expansion of the crypts and necrotic changes in lamina propria. In a previous study very long persistence of damage to the gastrointestinal tract by repeated exposures to AZA toxins was reported. In our study, full recovery from the pathological changes was observed seven days after a single exposure to AZA1 at the doses applied.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Brain metabolism
Female
Gastrointestinal Tract drug effects
Gastrointestinal Tract pathology
Kidney metabolism
Liver metabolism
Lung metabolism
Marine Toxins administration & dosage
Marine Toxins pharmacokinetics
Mice
Mice, Inbred Strains
Myocardium metabolism
Spiro Compounds administration & dosage
Spiro Compounds pharmacokinetics
Spleen metabolism
Time Factors
Toxicity Tests
Marine Toxins toxicity
Spiro Compounds toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3150
- Volume :
- 56
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Publication Type :
- Academic Journal
- Accession number :
- 20800607
- Full Text :
- https://doi.org/10.1016/j.toxicon.2010.08.007