Back to Search
Start Over
[The significance of radiation therapy for symptomatic vertebral hemangiomas (SVH)].
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2010 Aug; Vol. 186 (8), pp. 430-5. Date of Electronic Publication: 2010 Jul 29. - Publication Year :
- 2010
-
Abstract
- Purpose: To evaluate the efficacy of radiation therapy (RT) for symptomatic vertebral hemangioma (SVH).<br />Material and Methods: Based on the Registry for Rare Benign Disorders (RRBD) of the German Cooperative Group on Radiation Therapy for Benign Diseases (GCG-BD), the clinical information, treatment plans and outcome data from seven cooperating German RT institutions were analyzed retrospectively.<br />Results: Over a period of 39 years (1969-2008), a total of 84 patients with 96 symptomatic lesions underwent RT. The predominant indication was pain in 97.6%, and, in addition, 28.6% of patients had neurological deficits. The median total dose was 34 Gy (4.5-45 Gy), and the median single dose 2.0 Gy (0.5-3.0 Gy). After a median follow-up of 68 months (6-422 months), complete symptom relief (CR) occurred in 61.9% of patients, 28.6% had partial relief, and 9.5% had no relief (NR). The overall response rate (CR + PR) was 90.5%. In 26.2% of patients, radiologic signs of remineralization were noted. After a median follow-up of 70 months (8-124 months), symptom progression occurred in eight patients (9.5%). Therefore, the long-term rate of local control was 80.9%. Multivariate statistical analysis revealed a significantly higher rate of symptom relief and local control for total doses > or = 34 Gy. Side effects > RTOG/EORTC grade 2 were not observed.<br />Conclusion: RT is a safe and effective for treatment of SVH. Total doses of at least 34 Gy are recommended to achieve optimal treatment response.
- Subjects :
- Adolescent
Adult
Aged
Child
Female
Follow-Up Studies
Hemangioma diagnosis
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neurologic Examination
Radiotherapy Dosage
Registries
Retrospective Studies
Spinal Neoplasms diagnosis
Spinal Stenosis diagnosis
Spinal Stenosis radiotherapy
Tomography, X-Ray Computed
Treatment Outcome
Young Adult
Hemangioma radiotherapy
Spinal Neoplasms radiotherapy
Subjects
Details
- Language :
- German
- ISSN :
- 1439-099X
- Volume :
- 186
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 20803283
- Full Text :
- https://doi.org/10.1007/s00066-010-2140-3