Back to Search
Start Over
Effects of cypermethrin on monoamine transporters, xenobiotic metabolizing enzymes and lipid peroxidation in the rat nigrostriatal system.
- Source :
-
Free radical research [Free Radic Res] 2010 Dec; Vol. 44 (12), pp. 1416-24. Date of Electronic Publication: 2010 Sep 06. - Publication Year :
- 2010
-
Abstract
- Long-term exposure to cypermethrin induces the nigrostriatal dopaminergic neurodegeneration in adult rats and its pre-exposure in the critical periods of brain development enhances the susceptibility during adulthood. Monoamine transporters, xenobiotic metabolizing enzymes and oxidative stress play critical roles in the nigrostriatal dopaminergic neurodegeneration. The study was undertaken to investigate the effects of cypermethrin on DAT, VMAT 2, CYP2E1, GST Ya, GST Yc and GSTA4-4 expressions, CYP2E1 and GST activities and lipid peroxidation in the nigrostriatal system of adult rats with/without post-natal exposure to cypermethrin. Cypermethrin reduced VMAT 2 and increased CYP2E1 expressions without causing significant change in DAT. Although GSTA4-4 mRNA expression and lipid peroxidation were increased, no significant changes were observed in GST Ya and GST Yc expressions and total GST activity. The results obtained demonstrate that long-term exposure to cypermethrin modulates VMAT 2, CYP2E1, GSTA4-4 expressions and lipid peroxidation, which could contribute to the nigrostriatal dopaminergic neurodegeneration.
- Subjects :
- Animals
Corpus Striatum metabolism
Dopamine metabolism
Female
Male
Neural Pathways drug effects
Neural Pathways metabolism
Pregnancy
Rats
Rats, Wistar
Substantia Nigra metabolism
Corpus Striatum drug effects
Cytochrome P-450 CYP2E1 biosynthesis
Dopamine Plasma Membrane Transport Proteins biosynthesis
Glutathione Transferase biosynthesis
Lipid Peroxidation drug effects
Pesticides toxicity
Pyrethrins toxicity
Substantia Nigra drug effects
Vesicular Monoamine Transport Proteins biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2470
- Volume :
- 44
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Free radical research
- Publication Type :
- Academic Journal
- Accession number :
- 20815782
- Full Text :
- https://doi.org/10.3109/10715762.2010.512041