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[Positive sentinel node risk in relation to oestrogen receptors in breast cancer in premenopausal and postmenopausal women].
- Source :
-
Revista espanola de medicina nuclear [Rev Esp Med Nucl] 2010 Nov-Dec; Vol. 29 (6), pp. 289-92. Date of Electronic Publication: 2010 Sep 15. - Publication Year :
- 2010
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Abstract
- Objective: The influence of the relationship between pre- and post-menopausal stage of patients with breast cancer (BC) and the risk of sentinel lymph node (SLN) metastasis as well as the influence of oestrogen receptor (ER) status within each one of these groups were analyzed.<br />Methods: A BC database with 1,388 patients was analysed. Three age groups were studied: A, elderly postmenopausal, 200 patients, ≥ 70 years old; B, younger postmenopausal, 89 patients, 55-69 years old; C, premenopausal, 85 patients, <55 years old. In each group 2 subgroups were analyzed: positive ER and negative ER tumours. Data analysed: SLN-positive patients, non-sentinel node (NSN)-positive patients, non-surgical detections (NSD) and non disease-free (NDF) patients after a follow-up of 52 months.<br />Statistical Analysis: chi-squared test, significance: P ≤ 0.05.<br />Results: SLN metastasis was significantly (P<0.025) more common in premenopausal than in postmenopausal patients, and within those, mainly in negative ER tumours. Positive-NSN increases slightly in premenopausal patients (exclusively in negative ER tumours). NDF patients are similar in the 3 groups and in all of them it is much more frequent in negative ER tumours.<br />Conclusion: SLN metastasis varies significantly according to hormonal state and not according to age, being more frequent in premenopausal patients and mainly in ER negative tumours.<br /> (Copyright © 2010 Elsevier España, S.L. y SEMNIM. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Breast Neoplasms chemistry
Breast Neoplasms epidemiology
Carcinoma, Ductal, Breast chemistry
Carcinoma, Ductal, Breast epidemiology
Carcinoma, Ductal, Breast pathology
Female
Humans
Middle Aged
Neoplasms, Hormone-Dependent chemistry
Neoplasms, Hormone-Dependent epidemiology
Postmenopause
Premenopause
Prevalence
Retrospective Studies
Risk
Breast Neoplasms pathology
Carcinoma, Ductal, Breast secondary
Estrogens
Lymphatic Metastasis
Neoplasm Proteins analysis
Neoplasms, Hormone-Dependent pathology
Receptors, Estrogen analysis
Sentinel Lymph Node Biopsy
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0212-6982
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Revista espanola de medicina nuclear
- Publication Type :
- Academic Journal
- Accession number :
- 20828880
- Full Text :
- https://doi.org/10.1016/j.remn.2010.07.002